论著摘要 |【多模态】肿瘤血管性,血管内皮生长因子表达与原发性清除细胞 - 肾细胞癌中PET / MRI放射性标记之间的关联:概念证明研究(双语版)

2017-08-26 14:01:38 admin 36

Associations between Tumor Vascularity, Vascular Endothelial Growth Factor Expression and PET/MRI Radiomic Signatures in Primary Clear-Cell-Renal-Cell-Carcinoma: Proof-of-Concept Study.

发表日期:2017 Mar 3    来源:Sci Rep.

作者:Yin Q1,2Hung SC3,4,5Wang L2Lin W2Fielding JR6Rathmell WK7,8,9,10Khandani AH2Woods ME7,11Milowsky MI7,8,11Brooks SA7Wallen EM11Shen D2,12.

作者介绍:

    1.College of Information Science and Technology, Dalian Maritime University, Dalian, 116023, China.

    2.Department of Radiology, University of North Carolina, Chapel Hill, NC 27599, USA.

    3.Department of Radiology, Taipei Veterans General Hospital, Taipei, 11217, Taiwan.

    4.School of Medicine, National Yang-Ming University, Taipei, 11221, Taiwan.

    5.Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science of Engineering, National Yang-Ming University, Taipei, 11221, Taiwan.

    6.Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

    7.Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

    8.Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

    9.Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.

    10.Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA.

    11.Department of Urology, University of North Carolina, Chapel Hill, NC 27599, USA.

    12.Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea.

摘要

研究表明,肿瘤血管生成是肿瘤生长,增殖和转移的重要过程。 此外,肿瘤血管生成是透明细胞肾细胞癌(ccRCC)的重要预后因素,也是指导抗血管生成药物治疗的一个因素。 在这里,我们尝试从PET / MRI中找到肿瘤血管生成和放射成像特征之间的关联。 具体来说,对来自9个主要ccRCC患者的3个特征数据集进行稀疏规范相关分析(即辐射成像特征,肿瘤微血管密度(MVD)和血管内皮生长因子(VEGF)表达)。为了克服血管生成肿瘤内异质性的潜在偏差,本研究调查了血管生成和VEGF的区域表达与肿瘤内不同部位的局部放射学特征之间的关系。 我们的研究强调了放射性特征与MVD之间的显着的强相关性,并且还表明从DCE-MRI提取的时空特征提供了比从Dixon序列和FDG PET提取的纹理特征对MVD的更强的放射学相关性。 此外,利用组合的功能和结构信息的PET / MRI与单独使用PET或MRI相比,具有更高的与MVD的放射线相关性。

Studies have shown that tumor angiogenesis is an essential process for tumor growth, proliferation and metastasis. Also, tumor angiogenesis is an important prognostic factor of clear cell renal cell carcinoma (ccRCC), as well as a factor in guiding treatment with antiangiogenic agents. Here, we attempted to find the associations between tumor angiogenesis and radiomic imaging features from PET/MRI. Specifically, sparse canonical correlation analysis was conducted on 3 feature datasets (i.e., radiomic imaging features, tumor microvascular density (MVD), and vascular endothelial growth factor (VEGF) expression) from 9 patients with primary ccRCC. In order to overcome the potential bias of intratumoral heterogeneity of angiogenesis, this study investigated the relationship between regional expressions of angiogenesis and VEGF, and localized radiomic features from different parts within the tumors. Our study highlighted the significant strong correlations between radiomic features and MVD, and also demonstrated that the spatiotemporal features extracted from DCE-MRI provided stronger radiomiccorrelation to MVD than the textural features extracted from Dixon sequences and FDG PET. Furthermore, PET/MRI, which takes advantage of the combined functional and structural information, had higher radiomics correlation to MVD than solely utilizing PET or MRI alone.

阅读原文:10.1038/srep43356


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