论著摘要 |【MR】小鼠前列腺癌模型放射治疗后肿瘤内异质性的扩散影像学分析:像素与组织学的相关性(双语版)

2017-09-04 09:37:06 admin 63

Diffusion radiomics analysis of intratumoral heterogeneity in a murine prostate cancer modelfollowing radiotherapy: Pixelwise correlation with histology.

发表日期:2017.8.16    来源:J Magn Reson Imaging. 

作者:Lin YC1,2Lin G1,3,4Hong JH2,4,5Lin YP5Chen FH2,4,5Ng SH1,2Wang CC2,4,5.

作者介绍

    1.Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taiwan.

    2.Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taiwan.

    3.Clinical Phenome Center, Chang Gung Memorial Hospital at Linkou, Taiwan.

    4.Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University / Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

    5.Department of Radiation Oncology, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taoyuan, Taiwan.

目的:

研究放射治疗后肿瘤中表观扩散系数(ADC)的生物学意义。

To investigate the biological meaning of apparent diffusion coefficient (ADC) values in tumors following radiotherapy.

材料和方法:

5只携带TRAMP-C1肿瘤的小鼠以15Gy的剂量进行半照射。在第67T采集了使用03000s / mm2的多个b值的扩散加权图像。在肿瘤辐照和非辐照区域之间通过两点估计和信号衰减的单指数拟合计算的ADC值进行了比较。像素ADC图与组织学指标相对应,包括核计数,核尺寸,核空间,细胞质空间和细胞外空间。

Five mice bearing TRAMP-C1 tumor were half-irradiated with a dose of 15 Gy. Diffusion-weighted images, using multiple b-values from 0 to 3000 s/mm2 , were acquired at 7T on day 6. ADC values calculated by a two-point estimate and monoexponential fitting of signal decay were compared between the irradiated and nonirradiated regions of the tumor. Pixelwise ADC maps were correlated with histological metrics including nuclear counts, nuclear sizes, nuclear spaces, cytoplasmic spaces, and extracellular spaces.

结果:

与非照射区相比,照射区域ADC,细胞外空间和核尺寸显著增加,核数显著减少(均P <0.001)。通过两点法和单指数曲线拟合,以800 s / mm2b值可得到区分辐照区域和非照射区域的最佳ADC ADC与细胞外空间(r = 0.74)和核大小(r = 0.72)呈正相关,与核计数呈负相关(r = -0.82P<0.001)。

As compared with the nonirradiated region, the irradiated region exhibited significant increases in ADC, extracellular space, and nuclear size, and a significant decrease in nuclear counts (P < 0.001 for all). Optimal ADC to differentiate the irradiated from nonirradiated regions was achieved at a b-value of 800 s/mm2 by the two-point method and monoexponential curve fitting. ADC positively correlated with extracellular spaces (r = 0.74) and nuclear sizes (r = 0.72), and negatively correlated with nuclear counts (r = -0.82, P < 0.001 for all).

结论:

作为影像组学生物标志物,与组织学指标相关的ADC像素图可作为评估肿瘤异质性和放射治疗反应的一种手段。

As a radiomic biomarker, ADC maps correlating with histological metrics pixelwise could be a means of evaluating tumor heterogeneity and responses to radiotherapy.

关键词:

表观扩散系数,扩散磁共振成像,放射疗法



apparent diffusion coefficient; diffusion MRI; radiotherapy


阅读原文:10.1002/jmri.25583

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