论著摘要 |【综述】头颈癌个性化放疗治疗的未来(双语版)

2017-08-16 14:26:30 admin 4

The future of personalised radiotherapy for head and neck cancer.

发表日期:2017.3.11   来源:Lancet Oncol

作者:Caudell JJ1, Torres-Roca JF1, Gillies RJ2, Enderling H3, Kim S1, Rishi A1, Moros EG1, Harrison LB4.

作者介绍

    1.Department of Radiation Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

    2.Department of Cancer Imaging and Metabolism, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

    3.Department of Integrated Mathematical Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

    4.Department of Radiation Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA. 

摘要

长期以来,放射治疗一直是头颈部癌症患者的主要治疗方法,传统上涉及阶段依赖性策略,所有处于相同TNM分期的患者都接受相同的治疗。除了技术和解剖精度以外,我们相信提高改善放射治疗仍有很大的机会。在本系列论文中,我们探索了几个新的想法,可以提高对患者与肿瘤之间存在的表型和基因型差异的了解。我们讨论如何利用这些差异并利用精密医学工具(如基因组学,放射学和数学建模)可为开展个性化放射治疗的适应和治疗开辟新的大门。我们提出了一个新的治疗转移,从经验剂量和分次的时代转移到专注于指导个性化和放射治疗生物适应的证据发展的时代。 我们相信这些方法为提高治疗效果和降低毒性提供了可能性。

Radiotherapy has long been the mainstay of treatment for patients with head and neck cancer and has traditionally involved a stage-dependent strategy whereby all patients with the same TNM stage receive the same therapy. We believe there is a substantial opportunity to improve radiotherapy delivery beyond just technological and anatomical precision. In this Series paper, we explore several new ideas that could improve understanding of the phenotypic and genotypic differences that exist between patients and their tumours. We discuss how exploiting these differences and taking advantage of precision medicine tools-such as genomics, radiomics, and mathematical modelling-could open new doors to personalised radiotherapy adaptation and treatment. We propose a new treatment shift that moves away from an era of empirical dosing and fractionation to an era focused on the development of evidence to guide personalisation and biological adaptation of radiotherapy. We believe these approaches offer the potential to improve outcomes and reduce toxicity.


阅读原文:10.1016/S1470-2045(17)30252-8


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