论著摘要 |【PET】 非小细胞肺癌PET CT研究中放射组学特征的重复性(双语版)

2017-09-25 13:22:56 admin 0

Repeatability of Radiomic Features in non small cell lung cancer PET CT studies

发表日期: 2016.02.26   来源: Molecular Imaging and Biology, 2016, 18(5): 788–795.

作者

Floris H. P. van Velden1,2, Gerbrand M. Kramer1, Virginie Frings1,Ida A. Nissen1, Emma R. Mulder1, Adrianus J. de Langen3, Otto S. Hoekstra1, Egbert F. Smit3,4, Ronald Boellaard1,5

作者介绍:

1.Department of Radiology and Nuclear MedicineVU University Medical CenterAmsterdamThe Netherlands

2.Department of RadiologyLeiden University Medical CenterLeidenThe Netherlands

3.Department of Pulmonary DiseasesVU University Medical CenterAmsterdamThe Netherlands

4.Department of Thoracic OncologyNetherlands Cancer InstituteAmsterdamThe Netherlands

5.Department of Nuclear Medicine and Molecular ImagingUniversity Medical Center GroningenGroningenThe Netherlands

摘要

目的

评估(1)重复性和(2)重建方法和描述对非小细胞肺癌(NSCLC2-脱氧-2- [18 F]-D-葡萄糖的105个放射性特征的重复性的影响 [18F] FDG)正电子发射断层扫描/计算机断层扫描(PET / CT)研究。

Purpose

To assess (1) the repeatability and (2) the impact of reconstruction methods and delineation on the repeatability of 105 radiomic features in non-small-cell lung cancer (NSCLC) 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomorgraphy/computed tomography (PET/CT) studies.

步骤

11NSCLC患者接受了两次基线全身PET / CT扫描。 每次扫描重建两次,一次使用点扩散函数(PSF),一次遵循欧洲核医学协会(EANM)肿瘤PET成像指南。 感兴趣的卷(n = 19)被描绘了两次,一次在PET上,一次在CT图像上。

Procedures

Eleven NSCLC patients received two baseline whole-body PET/CT scans. Each scan was reconstructed twice, once using the point spread function (PSF) and once complying with the European Association for Nuclear Medicine (EANM) guidelines for tumor PET imaging. Volumes of interest (n = 19) were delineated twice, once on PET and once on CT images.

结果

六十三个特征显示了独立于描绘或重建的类内相关系数≥0.90 更多的特征对于划分的变化比对重建的变化(分别为253个特征)敏感。

Results

Sixty-three features showed an intraclass correlation coefficient  0.90 independent of delineation or reconstruction. More features were sensitive to a change in delineation than to a change in reconstruction (25 and 3 features, respectively).

结论

NSCLC [18F] FDG-PET / CT研究中的大多数特征与简单的标准摄取值测量相比,具有相似的高度重复性或更好。

Conclusions

The majority of features in NSCLC [18F]FDG-PET/CT studies show a high level of repeatability that is similar or better compared to simple standardized uptake value measures.

 

 关键词:

PET/CT,重复性,放射组学,示踪物摄取异质性,非小细胞肺癌

KEYWORDS:

PET/CT, Repeatability, Radiomics, Tracer uptake heterogeneity, Non-small-cell lung cancer (NSCLC)

阅读原文:doi:10.1007/s11307-016-0940-2

 


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