论著摘要 |【PET】 PET/CT 对肿瘤反应的评估——临床实践与影像组学研究的综述(双语版)

2017-10-18 11:29:30 admin 2

Positron Emission Tomography/Computerized Tomography for Tumor Response Assessment-A Review of Clinical Practices and Radiomics Studies.

发表日期: 2016.11.28   来源:Transl Cancer Res, 2016, 5(4):364-370.

作者:

Lu W1, Chen W2.

作者介绍:

1. Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, USA and Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.

2. Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, USA.

摘要

虽然近来在癌症诊断与治疗中取得了不少进展,但是一些癌症的治疗结果仍不容乐观。患者对于相同的治疗方法,经常表现出不同的反应,这一现象也激励着个性化医疗的发展。18F-FDG PET/CT已经被常规的应用到评估肿瘤反应,对结果进行预测,进而对个性化治疗进行指导。这些评价指标主要还是根据医生的主观半定量的评估。然而,最近影像组学中的一些进展中利用计算机化手段来提取大量的图像特征来捕捉目前未应用于临床上但能够提供预后价值的额外信息,为客观的肿瘤反应的评估提供了可能。本次综述中,我们总结了PET/CT的临床应用和PET/CT影像组学研究的肿瘤反应评估。最后,我们也讨论了这其中的一些挑战与未来的前景。

ABSTRACT

Even with recent advances in cancer diagnosis and therapy, treatment outcomes for many cancers remain dismal. Patients often show different response to the same therapy regimen, supporting the development of personalized medicine. 18F-FDG PET/CT has been used routinely in the assessment of tumor response, in prediction of outcomes, and in guiding personalized treatment. These assessments are mainly based on physician’s subjective or semi-quantitative evaluation. Recent development in Radiomics provides a promising objective way for tumor response assessment, which uses computerized tools to extract a large number of image features that capture additional information not currently used in clinic that has prognostic value. In this review, we summarized the clinical use of PET/CT and the PET/CT Radiomics studies for tumor response assessment. Finally, we discussed some challenges and future perspectives..

关键词:

18F-FDG PET/CT,放射组学,图像分析,肿瘤反应

KEYWORDS:

18F-FDG PET/CT; Radiomics; image analysis; tumor response

阅读原文:PMID: 27904837 PMCID: PMC5124903  DOI:10.21037/tcr.2016.07.12

 

 


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