论著摘要 |【Radiomics-MRI】早期乳腺癌术前MRI的多参数评估:肿瘤周围脂肪的预后影响(双语版)

2018-01-19 11:04:23 admin 0
标签:   影像组学 MRI 乳腺癌 脂肪组织 肥胖

Multiparametric evaluation of preoperative MRI in early stage breast cancer: prognostic impact of peri-tumoral fat.

发表日期: 2017.02.01   来源:Clin Transl Oncol. 2017 Feb;19(2):211-218.

作者:

Obeid JP1, Stoyanova R1, Kwon D2, Patel M1 , Padgett K1, Slingerland J3, Takita C1, Alperin N4, Yepes M4, Zeidan YH5.

作者介绍:

1. Department of Radiation Oncology, University of Miami Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Avenue, Suite 1500, Miami, FL, 33136, USA.

2. Biostatistics and Bioinformatics Core, University of Miami Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

3. Braman Family Breast Cancer Institute, University of Miami Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

4. Department of Radiology, University of Miami Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

5. Department of Radiation Oncology, University of Miami Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Avenue, Suite 1500, Miami, FL, 33136, USA. yzeidan@miami.edu.

摘要

Abstact

目的

肥胖与乳腺癌患者的不良结局相关。脂肪特异性细胞因子(脂肪因子)已经被指出是乳腺癌进展,侵袭和转移的关键驱动因素。我们旨在评估肿瘤周围脂肪,量化磁共振成像(MRI)和潜在影响治疗建议的病理因素之间的相关性。

Purpose

Obesity is associated with adverse outcomes in breast cancer patients. Fat-specific cytokines (adipokines) have been proposed as key drivers of breast cancer progression, invasion, and metastasis. We aimed at assessing correlations between peri-tumoral fat, quantified on magnetic resonance imaging (MRI) and pathologic factors potentially impacting therapy recommendations.

方法

我们回顾性地研究了使用乳腺和肿瘤轮廓适当加权的术前MRI成像的63例早期乳腺癌患者的记录。脂肪体积通过体素强度过滤产生。肿瘤周围区域被定义为肿瘤周围和乳房轮廓之间的1cm球形延伸的交叉区域。肿瘤周围脂肪被定义为该体积中脂肪含量的分数。手术病理记录用于提取临床资料。使用Pearson和Spearman相关系数进行统计分析。

Methods

We retrospectively reviewed records of 63 patients with early stage breast cancer who underwent preoperative MRI imaging using appropriately weighted series for breast and tumor contouring. Fat volumes were generated through voxel intensity filtering. The peri-tumoral region was defined as the intersection of a 1-cm spherical extension around the tumor and the breast contour. Peri-tumoral fat was defined as the fraction of a fat content in this volume. Surgical pathology records were used to extract clinical data. Statistical analyses were conducted using Pearson and Spearman correlation coefficients.

结果

在研究的患者中,45例有T1肿瘤(直径1.22±0.85 cm),18例T2肿瘤(2.08±1.06 cm)。31个患者的腋窝淋巴结切开分析,阳性17例。肿瘤周围脂肪比例在25%至99%之间。肿瘤周围脂肪率与阳性腋窝淋巴结的淋巴结阳性率显著相关(r = 0.532)。肥胖患者的肿瘤周围脂肪比率在体重指数分类分级后显示出最突出的相关性。

Results

Among reviewed patients, 45 had T1 tumors (1.22 ± 0.85 cm diameter) and 18 had T2 tumors (2.08 ± 1.06 cm). Axillary lymph nodes were dissected in 31 and positive in 17 patients analyzed. Peri-tumoral fat ratio ranged between 25 and 99 %. Peri-tumoral fat ratio significantly correlated with the nodal-positive ratio of positive axillary lymph nodes (r = 0.532). Peri-tumoral fat ratio demonstrated optimally prominent correlation among obese patients upon body mass index categorical stratification.

结论

在具有早期乳腺癌的妇女中,肿瘤周围脂肪与病理性腋窝淋巴结的比例呈正相关。这项工作突出了一种量化周质脂肪含量的新方法。术前乳腺MRI可用于预测腋窝疾病的程度。

Conclusions

In women with early stage breast cancer, peri-tumoral fat correlates positively with the ratio of pathologically involved axillary nodes. This work highlights a novel method for quantitating peri-tumoral fat content. Preoperative breast MRI may be utilized to predict extent of axillary disease.

关键词:

脂肪组织;乳腺癌;MRI;影像组学

Keywords:

Adipose tissue; Breast cancer; MRI; Radiomics

阅读原文:PMID: 27364695  DOI: 10.1007/s12094-016-1526-9


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