论著摘要 |【Radiomics-MR】对于T2加权MRI Haralick纹理特征与放射治疗后周围区前列腺癌的生化复发有关(双语版)

2018-01-22 13:41:38 admin 0
标签:   影像组学 MRI 前列腺癌 T2加权图像 放疗 纹理分析

Haralick textural features on T2 -weighted MRI are associated with biochemical recurrence following radiotherapy for peripheral zone prostate cancer.

发表日期: 2017.01.01   来源:J Magn Reson Imaging. 2017 Jan;45(1):103-117.

作者:

Gnep K1,2,3, Fargeas A1,2, Gutiérrez-Carvajal RE1,2 , Commandeur F1,2, Mathieu R1,2,4, Ospina JD1,2, Rolland Y5, Rohou T6,5, Vincendeau S4 , Hatt M7, Acosta O1,2, de Crevoisier R1,2,3.

作者介绍:

1. INSERM, U1099, Rennes, France.

2. Université de Rennes 1, LTSI, Rennes, France.

3. Department of Radiotherapy, Centre Eugène Marquis, Rennes, France.

4. Department of Urology, Centre Hospitalier Universitaire Pontchaillou, Rennes, France.

5. Department of Radiology, Centre Eugène Marquis, Rennes, France.

6. Department of Radiology, Centre Hospitalier Universitaire Pontchaillou, Rennes, France.

7. LaTIM, INSERM UMR 1101, University of Brest, France.

摘要

Abstact

目的

探讨磁共振成像(MRI)之间的联系,包括Haralick纹理特征以及前列腺癌放射治疗后的生化复发。

Purpose

To explore the association between magnetic resonance imaging (MRI), including Haralick textural features, and biochemical recurrence following prostate cancer radiotherapy.

材料和方法

总共74例外周区局部前列腺腺癌患者在外放射治疗前进行3.0T MRI预处理。 47个月的中位随访显示11例生化复发患者。 前列腺肿瘤在T2加权序列(T2-w)上被分割,并且轮廓被传播到核心观察的表观扩散系数(ADC)图像上。 我们从对应于一阶(n = 6),基于梯度(n = 4)和二阶哈拉利克纹理特征(n = 130)的标准化T2-w和ADC图像提取140个图像特征。 还计算了四个几何特征(肿瘤直径,周长,面积和体积)。 评估Gleason评分和MRI特征之间的相关性。 进行Cox回归分析和随机生存林(RSF)评估MRI特征与生化复发之间的关系。

Material and methods

In all, 74 patients with peripheral zone localized prostate adenocarcinoma underwent pretreatment 3.0T MRI before external beam radiotherapy. Median follow-up of 47 months revealed 11 patients with biochemical recurrence. Prostate tumors were segmented on T2 -weighted sequences (T2 -w) and contours were propagated onto the coregistered apparent diffusion coefficient (ADC) images. We extracted 140 image features from normalized T2 -w and ADC images corresponding to first-order (n = 6), gradient-based (n = 4), and second-order Haralick textural features (n = 130). Four geometrical features (tumor diameter, perimeter, area, and volume) were also computed. Correlations between Gleason score and MRI features were assessed. Cox regression analysis and random survival forests (RSF) were performed to assess the association between MRI features and biochemical recurrence.

结果

三个T2-w和一个ADC Haralick纹理特征与Gleason评分显着相关(P < 0.05)。 二十八个T2-w Haralick特征和所有四个几何特征与生化复发显着相关(P < 0.05)。 最相关的特征是Haralick特征T2-w对比度,T2-w差异方差,ADC中位数,以及肿瘤体积和肿瘤面积(C指数从0.76到0.82; P < 0.05)。 通过在RSF模型中组合这些最强大的特征,获得的C指数为0.90。

Results

Three T2-w and one ADC Haralick textural features were significantly correlated with Gleason score (P < 0.05). Twenty-eight T2-w Haralick features and all four geometrical features were significantly associated with biochemical recurrence (P < 0.05). The most relevant features were Haralick features T2-w contrast, T2-w difference variance, ADC median, along with tumor volume and tumor area (C-index from 0.76 to 0.82; P < 0.05). By combining these most powerful features in an RSF model, the obtained C-index was 0.90.

结论

T2-w Haralick特征似乎与前列腺癌放射治疗后的生化复发密切相关。

Conclusions

T2-w Haralick features appear to be strongly associated with biochemical recurrence following prostate cancer radiotherapy.

关键词:

T2加权图像;图像生物标记;核磁共振成像;前列腺癌;放射组学;放疗;纹理分析

Keywords:

T2-weighted imaging; imaging biomarkers; magnetic resonance imaging; prostate cancer; radiomics; radiotherapy; texture analysis

阅读原文:PMID: 27345946  DOI: 10.1002/jmri.25335


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