论著摘要 |【Radiomics-综述】影像学和循环肿瘤细胞:肝细胞癌的个性化护理?(双语版)

2018-02-24 10:22:13 admin
标签:  影像组学  肝细胞癌

Radiomics and circulating tumor cells: personalized care in hepatocellular carcinoma?

发表日期: 2015.01.01   来源:Diagn Interv Radiol. 2015 Jan-Feb;21(1):78-84.

作者:

Hesketh RL1, Zhu AX, Oklu R.

作者介绍:

1. West Middlesex University Hospital, London, UK. roklu@mgh.harvard.edu.

摘要

由于我们越来越多地了解推动肿瘤的分子机制和靶向这些驱动因素的能力,预计肿瘤学中的个性化护理将显着提高发病率和死亡率。 尽管局部疾病是可治愈的,肝细胞癌具有非常高的发病率和死亡率,所以强调早期诊断是非常重要的。影像学是使用成像技术推断分子肿瘤数据,以及循环肿瘤细胞(CTC)的检测是可以相对容易地并入临床环境的两种新技术。在这里,我们讨论导致肝细胞癌发展的分子机制,重点关注肝脏磁共振成像,CTC和放射治疗技术的最新发展及其改善诊断,分期和治疗的潜力。

Abstact

Personalized care in oncology is expected to significantly improve morbidity and mortality, facilitated by our increasing understanding of the molecular mechanisms driving tumors and the ability to target those drivers. Hepatocellular carcinoma has a very high mortality to incidence ratio despite localized disease being curable, emphasizing the importance of early diagnosis. Radiomics, the use of imaging technology to extrapolate molecular tumor data, and the detection of circulating tumor cells (CTCs) are two new technologies that could be incorporated into the clinical setting with relative ease. Here we discuss the molecular mechanisms leading to the development of hepatocellular carcinoma focusing on the latest developments in liver magnetic resonance imaging, CTC, and radiomic technology and their potential to improve diagnosis, staging, and therapy.

阅读原文:PMID: 25430530  PMCID: PMC4463354  DOI: 10.5152/dir.2014.14237


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