论著摘要 |【Radiomics-CT】重复CT在直肠癌影像组学研究中的可再现性

2018-05-16 16:48:43 admin
标签:   影像组学 直肠癌 CT 纹理特征 可重现性

Reproducibility with repeat CT in radiomics study for rectal cancer.

发表日期: 2016.11.01   来源:Oncotarget. 2016 Nov 1;7(44):71440-71446.

作者:

Hu P1,2, Wang J1,2, Zhong H1,2, Zhou Z1,2, Shen L1,2, Hu W1,2, Zhang Z1,2.

作者介绍:

1. Department of Radiotherapy, Fudan University Shanghai Cancer Center, Shanghai, China.

2. Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China.

摘要

Abstact

目的

通过在直肠癌中重复计算机断层扫描(CT)来评估影像组学特征的再现性,为直肠癌选择稳定的影像组学特征。

Purpose

To evaluate the reproducibility of radiomics features by repeating computed tomographic (CT) scans in rectal cancer. To choose stable radiomics features for rectal cancer.

结果

体积标准化的特征比未标准化的特征再现性好很多。所有切片的平均值是直肠癌中最可重现的特征类型。不同的滤波器对于影像组学特征的再现性几乎没有影响。对于平均类型特征,775个特征中的496个显示出高再现性(ICC≥0.8),775个特征中的225个显示中等重现性(0.8>ICC≥0.5),并且775个特征中的54个显示低重现性(ICC<0.5)。

Results

Volume normalized features are much more reproducible than unnormalized features. The average value of all slices is the most reproducible feature type in rectal cancer. Different filters have little effect for the reproducibility of radiomics features. For the average type features, 496 out of 775 features showed high reproducibility (ICC ≥ 0.8), 225 out of 775 features showed medium reproducibility (0.8 > ICC ≥ 0.5) and 54 out of 775 features showed low reproducibility (ICC < 0.5).

方法

本研究纳入了40例直肠癌II期患者,平均每8.7天接受两次CT扫描。本研究定义了775个影像组学特征。对于每个特征,提取五个不同的值(来自最大切片的值,最大值,最小值,所有切片的平均值和来自叠加中间矩阵的值)。同时对这些图像应用具有不同参数的LOG滤波器以找到稳定的滤波值。计算两个CT扫描的一致性相关系数(CCC)和类间相关系数(ICC),以基于原始特征和体积归一化特征评估再现性。

Methods

40 rectal cancer patients with stage II were enrolled in this study, each of whom underwent two CT scans within average 8.7 days. 775 radiomics features were defined in this study. For each features, five different values (value from the largest slice, maximum value, minimum value, average value of all slices and value from superposed intermediate matrix) were extracted. Meanwhile a LOG filter with different parameters was applied to these images to find stable filter value. Concordance correlation coefficients (CCC) and inter-class correlation coefficients (ICC) of two CT scans were calculated to assess the reproducibility, based on original features and volume normalized features.

结论

建议在影像组学分析中将特征体积标准化。平均类型影像组学特征是直肠癌中最稳定的特征。对于直肠癌的这些特征的进一步分析可以用于治疗监测和预后预测。

Conclusions

Features are recommended to be normalized to volume in radiomics analysis. The average type radiomics features are the most stable features in rectal cancer. Further analysis of these features of rectal cancer can be warranted for treatment monitoring and prognosis prediction.to modulate two anticancer compounds in well-defined sets of GBM patients.

关键词:

影像组学,直肠癌,可重复性,纹理特征

Keywords:

radiomics; rectal cancer; reproducibility; textural features

阅读原文:PMID: 27669756  PMCID: PMC5342090  DOI: 10.18632/oncotarget.12199


慧影医疗科技(北京)有限公司

地点:北京市海淀区中关村东升科技园B2-C103

电话:400-890-9020

邮箱:radcloud@huiyihuiying.com

关闭
图片
图片